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Early Manifestations of Cystic Fibrosis (CF) Lung Disease

Watch global experts in cystic fibrosis (CF) discuss how clinical research has informed their practice techniques.

  • Cystic Fibrosis: Identifying Early Disease

    The panel discusses the identification and diversity of early lung disease in patients with CF.

    “Different tests will identify abnormalities in different children. An infant can have airway obstruction but no clear evidence of infection or inflammation. However, there’s a link between those measures.”
    Dr. Felix Ratjen

  • Cystic Fibrosis: Diagnostic Testing in Infants

    The experts outline their own practice habits and how they analyze early disease in patients who may lack visible symptoms.

    “Our practice patterns reflect a certain risk-benefit ratio that we have in our minds. But that may not be the right approach, because there are probably many children who would have evidence of lung disease if we did routine CT scans or BAL that we missed because we’re waiting for symptoms.”
    Dr. Margaret Rosenfeld

  • Cystic Fibrosis: Disease Management

    The panel discusses how diagnostic procedures allow patients to be stratified according to risk, and the hierarchy of interventions used to treat them.

    “We would be treating the underlying infection but also targeting inflammation as well — the two of them really go hand in hand, along with obstruction of the airways by thick secretions. That helps guide us a little bit better as far as how more aggressive to intervene in that particular baby.”
    Dr. Michael Konstan

  • Cystic Fibrosis: Coming to Consensus

    The panel discusses the alignment between evidence-based guidelines/research and what happens in routine clinical practice.

    “In terms of how this has changed our approach, some of it is recognition that you don’t have to be symptomatic to have significant lung disease.”
    Dr. Sarath Ranganathan

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Meet Our Panel of Cystic Fibrosis Experts

Michael Konstan, MD

Michael Konstan, MD »

Professor and Chairman, Department of Pediatrics, Case Western Reserve University School of Medicine

UH Rainbow Babies & Children’s Hospital, Cleveland, OH

Margaret Rosenfeld, MD MPH

Margaret Rosenfeld,
MD MPH »

Professor of Pediatrics, Division of Pulmonary Medicine, Seattle Children’s Hospital

University of Washington School of Medicine, Seattle, WA

Sarath Ranganathan, MBChB FRCPCH FRACP PhD

Sarath Ranganathan, MBChB FRCPCH FRACP PhD »

Director of Respiratory Medicine, Royal Children’s Hospital Melbourne

Head, Respiratory Group, Murdoch Children’s Research Institute

Senior Fellow, Department of Pediatrics, University of Melbourne

Felix Ratjen, MD FRCP(C)

Felix Ratjen, MD FRCP(C) »

Division Head, Pediatric Respiratory Medicine, The Hospital for Sick Children

Professor, Pediatrics, University of Toronto, Canada

Patrick Flume, MD

Patrick Flume, MD »

Professor of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC

Dutch VanDevanter, Moderator

Dutch VanDevanter,
Moderator »

Adjunct Associate Professor of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH

Roundtable participants have been compensated by Genentech to serve as faculty for this program.