Cystic Fibrosis: Identifying Early Disease
The panel discusses the identification and diversity of early lung disease in patients with CF.
“Different tests will identify abnormalities in different children. An infant can have airway obstruction but no clear evidence of infection or inflammation. However, there’s a link between those measures.”
Dr. Felix Ratjen
Cystic Fibrosis: Diagnostic Testing in Infants
The experts outline their own practice habits and how they analyze early disease in patients who may lack visible symptoms.
“Our practice patterns reflect a certain risk-benefit ratio that we have in our minds. But that may not be the right approach, because there are probably many children who would have evidence of lung disease if we did routine CT scans or BAL that we missed because we’re waiting for symptoms.”
Dr. Margaret Rosenfeld
Cystic Fibrosis: Disease Management
The panel discusses how diagnostic procedures allow patients to be stratified according to risk, and the hierarchy of interventions used to treat them.
“We would be treating the underlying infection but also targeting inflammation as well — the two of them really go hand in hand, along with obstruction of the airways by thick secretions. That helps guide us a little bit better as far as how more aggressive to intervene in that particular baby.”
Dr. Michael Konstan
Cystic Fibrosis: Coming to Consensus
The panel discusses the alignment between evidence-based guidelines/research and what happens in routine clinical practice.
“In terms of how this has changed our approach, some of it is recognition that you don’t have to be symptomatic to have significant lung disease.”
Dr. Sarath Ranganathan
Meet Our Panel of Cystic Fibrosis Experts
Michael Konstan, MD »
Professor and Chairman, Department of Pediatrics, Case Western Reserve University School of Medicine
UH Rainbow Babies & Children’s Hospital, Cleveland, OH
MD MPH »
Professor of Pediatrics, Division of Pulmonary Medicine, Seattle Children’s Hospital
University of Washington School of Medicine, Seattle, WA
Sarath Ranganathan, MBChB FRCPCH FRACP PhD »
Director of Respiratory Medicine, Royal Children’s Hospital Melbourne
Head, Respiratory Group, Murdoch Children’s Research Institute
Senior Fellow, Department of Pediatrics, University of Melbourne
Felix Ratjen, MD FRCP(C) »
Division Head, Pediatric Respiratory Medicine, The Hospital for Sick Children
Professor, Pediatrics, University of Toronto, Canada
Patrick Flume, MD »
Professor of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC
Adjunct Associate Professor of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH